This has been a problem ever since i started using the new package. Keys such as Q, W, E, A, S, D, F, G, Z, X, C, and V don't work when using them to shortcut selecting mods. Also, number keys don't work to shortcut in menu's (take the beatmap options menu for example) by pressing 1, 2, 3, etc. to select an option.
In the editor, using the space bar, using Q, W, and/or E to quick select whistle, finish, and clap, and other such features do not work either.
In a recent update, something broke the old osu package (the one running on the custom InfinityRaw engine, unlike the current one which runs a basic Wine-provided engine) causing it to always open up the same two errors. First being an error saying that something serious has occured with winemenubuilder.exe, then another that says osu has encountered a problem and needs to close.
