For any practical application, there are some slight advantages to using certain key binds over others:
- Using a wider setup like [a][s][5][6] allows your wrists and elbows to align properly, improving your posture and preventing any wrist pain from bending in your fingers, but it isn't much of an issue unless you play several hours a day
- Using the upper row of keys like [q][w][8][9] can possibly increase stamina and vibro ability as your finger travels less distance to register a note, but this can be easily remedied by elevating your keyboard
- Using the lower or middle rows of keys can make curling your fingers more natural, which prevents fingerlocking and discomfort, but those issues can be easily fixed by CURLING YOUR FINGERS
- Numpad can be dangerous in the off chance you turn it off in the middle of a song
- From my experience, using the arrow keys or a non linear setup like [j][i][k][l] can make certain patterns like jackhammering or vibroing awkward, but still doable