(tldr at the end) i've done a little bit of research on the muscles used in your hand. the benefit of using your index and middle finger on 2 hands is that there is a muscle on your hand which allows your index finger to move freely. there is no such muscle for your middle, ring and pinky fingers, as the muscles which allow movement for these 3 fingers are just one muscle. this is why it's very difficult to move your ring finger on its own, because it's in the middle of this muscle. that said, your middle and pinky fingers are a bit easier to move independently because they're on opposite sides of this muscle.
when you play with one hand, no matter what you do, you're always going to be over-utlizing the muscle responsible for movement of your ring, pinky and middle fingers. this just puts a guranteed handicap on your play no matter how you go about playing.
that said, playing with 2 fingers decreases the utilization of this muscle. the middle finger has a lot of mobility if you do not add in the ring or pinky fingers, since the muscle can move all of those fingers with the middle finger as opposed to having to stretch and stress this muscle by using 4 fingers in one hand.
using your index and middle fingers is the most common playstyle. since there's a dedicated muscle to allow you to move your index finger independently, it is the most mobile finger in your hand. the second most mobile finger in the middle finger, because its on the edge of the muscle responsible for moving the pinky, ring and middle fingers. the pinky is on the other edge but is not as viable for vsrg play because it's a small and weak finger compared to the middle finger.
tl;dr: due to the way the muscles in your hand work, using one hand severely kimits your mobility for 4k. use your middle and index fingers on each hand to maximize mobility