I used to be a rmb/lmb clicker and got pretty far with that setup.
It's not like anything is that much of a problem given a large amount of practice, but whenever a beatmap gets at a certain intensity inevitably it's gonna get in your way.
Fact is that clicking is majorly crippling to mouse-control and maps such as kirby mixes, and also any insane/lunatic map with focus on streaming or jumping, are much simpler once you're accustomed to x/z. The only thing I miss about clicking is that I didn't have to use my lousy left hand for anything
I also recommend trying hybrid play (click/x), unless you've got a tablet. It's darn difficult, but mastering it would give you a huge potential at streaming.