As keyboard bindings are adjustable, I'm not sure why mouse buttons aren't. The main issue is that one of the side mouse buttons pauses the game, and depending on the physical design of your mouse and your grip, it can be quite likely that you will accidentally hit this button in the middle of an intense section, generally ruining that playthrough.
I have searched around but haven't seen a setting for this, and since it should be very easy, I think it's a very reasonable request.
I have searched around but haven't seen a setting for this, and since it should be very easy, I think it's a very reasonable request.