Having hypermobile joints has not been an issue in terms of actual playability for me. The only bad thing I've suffered from is increased risk of getting RSI due to increased strain on the muscles near joints - which is something I've had to deal with, but am now basically fully recovered from RSI.
I do experience that after about a minute of play, I can crack my knuckles and repeat the process again by playing for another minute. Dunno if that's a thing for everyone but it's kind of annoying to feel that restriction of movement I get from "recharging" that cracking thing.