Insignificance? hell yeah, count me in!
...but yeah, it's a pretty common feeling, yet is kinda complex in terms of actually processing it. It's not that no one recognizes me for anything, or anything like that, but rather that we don't really have much of an impact on most people unless we really reach out, but when we're holed up in home, wondering what the fuck we're doing with our lives, and we haven't really talked to many people, then...
...you probably would only matter to those near you, which in this case, may not be that many.
So... yeah.
Have you thought that people should grow the fuck up and leave each other alone, just because you got tired of dealing with people? (I'd say no, personally)