- Full-area can provide better accuracy initially/overall, but it causes you to work/move more.
- Smaller-area is the opposite; you can have worse accuracy initially (and improve over-time), but it causes you to work/move less.
- I don't know if there's some scientific method for finding a "good" area if you aren't using full; you'll probably just want to find a good one by messing around with it. Just note that osu!'s circle area regardless of in-game resolution is a 4:3 square.
- Getting used to a tablet area and then changing it will likely produce lower scores initially. This either means you have to get used to the new area, or you just can't physically/mentally use it (changing the area isn't guaranteed to produce good results all the time).
- You'll likely have best results with osu! if you do not install any tablet drivers under Windows. Wacom's drivers in the past (may still do?) add some latency and other interaction/gestures with the pen movement which isn't useful for osu! (but might be useful for drawing and etc).
- Under Linux, if the tablet doesn't "just work", if it's a Wacom tablet, most distros provide a xorg wacom driver you can install. Gnome Settings also provides a nice GUI tablet manager app, and I'm pretty sure Plasma 5 does too. There's also some cool command-line stuff you can do for tablet management (mapping or disabling buttons/taps, area) too if you want to be able to have a consistent set-up.
I use full-area with a Huion H420; I find full area fun, and imo it looks cooler to spectators :p I also use Linux where my tablet "just works"; Window 8.1 and 10 messed with my tablet far more than I cared for (between tablet gestures and USB power saving/polling rate mucking).