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Best Binding of Isaac: Rebirth run

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Galagrawr
For all of you that play it, what's your best (or favorite) Binding of Isaac: Rebirth run?

btw, Soy Milk + Ipecac = No Bueno
alpha486
sirscrafty_old
Typical one but my best so far is Tech and Sacred Heart
Gumpy
I got to mom on my first run with lasers and shit
never gotten that far again
Jing Yuan
I got brimstone then lost contact once

I somehow threw on the dark room
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