Click me!I think this still applies to the current Intuos tablets from Wacom. ^
DON'T use the mouse mode on the your tablet.
Use the largest area as possible that you find
comfortable.
Stick with one area and never change it to build muscle memory.
Don't get frustrated right away because it may take time adjusting to.
Try to keep your pen really close to tablet and eventually you'll get the hang of it. (remember it is better to bump your tablet with pen every once in awhile than lifting to high)