I think with a little research you could've found out yourself already, and there should be threads about this too.
Anyways, install the drivers for your operating system (which will be installed automatically when connecting the device or manually through the bamboo wacom's website).
Then just go to Wacom Preferences and change how you want it (I recommend 'Pen Mode', with forced proportions and make the tablet area the size you think is best (find this out yourself by trying different sizes). There is also a way to turn off 'Flicks', into Control Panel > Pen and Touch. There are guides what to turn off or just use a registry program that sets the settings for you.
Also, if you have any trouble in game with the pen clicking, turn of mouse clicks in game (short cut F10).