I'm getting a Zowie AM, it's known for having an amazing sensor, although the DPI button is on the bottom of the mouse, i don't see why that should bother you to much.
Features:
* Ambidextrous mouse developed by legendary CS-player Abdisamad ‘SpawN’ Mohamed
* Two thumb buttons on both sides to comfortably serve left- or right-handed users
* Easy to switch between left- and right-hand functionality, no drivers needed
* Optical encoder mouse wheel system for increased durability
* 450 / 1150 / 2300 DPI adjustment
* Adjustable USB report rate 125 / 500 / 1000 Hz
* ZOWIE custom-designed lens for a very low lift-off distance = 1.5 ~ 1.8mm
* Operating system: Win2000/XP/VISTA/7, Mac OS X v10.2 after
Specifications:
* DPI (Dots Per Inch): 450/1150/2300
* Connector: USB
* Buttons: 5
* Length of cable: 2m / 6.6 ft
Measurements:
Length: 125 mm / 4.92 in
Width: 60 mm / 2.36 in
Height: 39mm / 1.53 in
Weight: 88g (without cable)
http://www.zowiegear.com/component/cont ... rous-mouseI'm more recommending this because of the sensor more then anything.
it's a bit of a small mouse i know and you said you had big hands, but it is a great mouse for gaming, generally FPS games, but with that sensor i would recommend it for any game that needs precision.